Antimicrobial
Lincosamides (clindamycin)
50S peptidyl-transferase blocker, anaerobe-active
lin-KOH-suh-mides
High-yield clue
Clindamycin binds the 50S subunit and shares the MLSb (erm-mediated) inducible resistance tested by the D-test.
Overview
A protein-synthesis class represented by clindamycin, studied for blocking the 50S peptidyl transferase center and for anaerobe and Gram-positive activity plus its inducible-resistance test concept.
Classification
- Protein-synthesis inhibitor
- Binds 50S ribosomal subunit
- Bacteriostatic
- Anaerobe and Gram-positive spectrum
Lab & identification clues
- Inducible clindamycin resistance (D-test) vocabulary
- MLSb / erm methylase resistance concept
- Overlapping 50S binding site with macrolides
Associations
- Toxin-suppression (anti-exotoxin) adjunct vocabulary
- Clostridioides difficile association concept
- Above-diaphragm anaerobe coverage vocabulary
Commonly confused with
- Macrolides
- Oxazolidinones (linezolid)
Your notes
Original mechanism summary for microbiology study. Sources checked: CDC antimicrobial-resistance guidance, NCBI Bookshelf Medical Microbiology, and standard coursework frameworks; reviewed 2026-06. Covers class, mechanism, and resistance vocabulary only; no prescribing, dosing, or patient-specific treatment guidance.